Synthesis and pharmacological evaluation of (6-substituted 4-Oxo-4 H -chromene-3 yl) methyl N-substituted aminoacetates
1Medicinal Chemistry Research Lab, University College of Pharmaceutical Sciences, Kakatiya University, India 2Vaagdevi College of Pharmacy, Ram Nagar, Kakatiya University, India
G Achaiah, Medicinal Chemistry Research Lab, University College of Pharmaceutical Sciences, Kakatiya University, India, E-mail: [email protected]
A series of the title compounds were synthesized and characterized by spectral data. All the compounds were evaluated for in vitro antihistaminic activity by inhibition of isotonic contractions induced by histamine on isolated guinea pig ileum and the compound 6-k showed significant activity. A few compounds have also been screened for in vivo bronchodilatory activity. These compounds exhibited significant protection against histamine-induced convulsions in guinea pig at the dose of 50 µmol.