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Abstract

Synthesis of 9-beta-d-glycopyranosyl xanthotoxal and cns depressant activity of 9 beta-d-arabinopyranosyl xanthotoxol.

Author(s): SM Jain, KK Anand, BK Chandan, CK Atal
Regional Research Laboratory, Canal Road, Jammu-180 001

Correspondence Address:
S M Jain Regional Research Laboratory, Canal Road, Jammu-180 001

A series of beta-D-glycopyranosyl xanthotoxol derivatives has been synthesised and screened for CNS depressant activity. The more active CNS depressant,9-beta-D-arabinopyranosyl xanthotoxol (IX), was selected for detailed study on different pharmacological parameters. It caused dose dependent inhibition of spontaneous motor activity, prolongation of hexabarbitone, pentobarbitone and ether hypnosis.