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Abstract

Synthesis of a new series of 1-(arylideneamino)-3-(4'-substituted sulphone)-guanidines as hypoglycemic agents

Author(s): VR Agarwal, DD Mukerji
Dept. of Chemistry, University of Lucknow, Lucknow 226 007

Correspondence Address:
V R Agarwal Dept. of Chemistry, University of Lucknow, Lucknow 226 007

Eight title compounds were synthesized by refluxing 1-(arylidene)-S-methylthiosemicarbazide with appropriate sulphonamides and their structures established by elemental analyses and spectral (IR, PMR) studies. In pharmacological screening, the compounds showed a reduction in blood glucose level upto 25 in rats at an oral dose of 250 mg/kg (tolbutamide 40 percent)