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Abstract

Target Oriented Microspheres Of Diclofenac Sodium

Author(s): Sulekha Bhadra, P Choubey, D Bhadra, G.P Agrawal

Bovine serum albumin microspheres of diclofenac sodium were prepared by emulsion polymerization technique and the gelatin microspheres were prepared by gelation and dehydration technique. These microspheres were prepared for targeting of diclofenac sodium to inflammation site. The silicone coated magnetite particles were prepared and used for-the preparation of magnetic microspheres. Effect of different formulation and process variables was studied on particle size, drug entrapment, in vitro release rate, magnetic responsiveness, biodistribution and stability of the microspheres.