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Abstract

Taste Masking Of Quinine Sulphate

Author(s): Vandana B Patravale, Namita B Prabhu

Quinine sulphate, an antimalarial agent, is extremely bitter in taste. The present communication deals with development of taste-masked resinates of quinine sulphate using ion exchange resins. The drug resin complexation procedure was optimized with respect to parameters like drug to resin ratio, volume of medium and taste of the complex. The taste-masked complex was then formulated into a prototype suspension base. The suspension was evaluated for various quality control parameters. Taste evaluation of the suspension showed complete masking of the bitterness of the drug. In vitro release studies revealed complete drug elution from the complex after a period of 30 min in pH 1.2 buffer.