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Abstract

Technological Potential of Antimicrobial Peptides: a Systematic Review

Author(s): E. Machado, Jane Gelinski1*, C. M. Baratto1, E. M. Borges2, Vania A. Vicente3, Mariana M. F. Nascimento3 and G. G. Fonseca1 4
Federal Institute of Education, Science and Technology Sul-Rio-Grandense, RS, 1University of the West of Santa Catarina, SC, 2Regional University of Blumenau, 3SC, Federal University of Parana, PR, 4Federal University of Grande Dourados, MS, Brazil

Correspondence Address:
Federal Institute of Education, Science and Technology Sul-Rio-Grandense, RS, University of the West of Santa Catarina, SC, 2Regional University of Blumenau, Brazil, E-mail: [email protected]


Resistance to antibiotics has being considered one of the greatest public health problems worldwide. The objective of this systematic review was to compile important bibliographical references that support the studies related to the biotechnological potential of antimicrobial peptides. Antimicrobial peptides are considered the major components of the innate immune system and work in defence against infections caused by different microorganisms. Many researchers argue that the studies associated with the discoveries of antimicrobial peptides that are more effective in the treatment of infections caused by microorganisms be also directed to the substances produced by insects. The major aspects associated to the technological potential of antimicrobial peptides are, general characteristics, classification, mode of action and prospects for applying, mainly in the pharmaceutical industry. It can be concluded that research for new substances with action against pathogenic microorganisms aim mainly to seek alternatives to the use of antibiotics. In addition, anticancer peptides are small cationic molecules with promising pharmacological use. However, the products for application in the protection of food, treatment of skin infections and its use in the cosmetics industry are those with the greatest potential.



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