Transdermal Delivery Of Ampicillin Sodium Patch Made From Volatile Vehicle
The permeation of ampicillin sodium patch from ethanol/pH4.7 buffer solution containing antinucleant polymers across mouse skin, was investigated. The in vitro release of ampicillin sodium was determined under open condition at 25o and 65% relative humidity. Therefore the influence of evaporation of vehicle components on the permeation of ampicillin sodium was examined. Evaporation of the vehicle led to drastic compositional changes leading to supersaturation. However, supersaturation solutions started to crystallize reducing the thermodynamic activity of ampicillin sodium. Antinucleant polymers where used in the preparation of volatile vehicles in order to maintain the Increased activity state of the drug. Carboxymethylcellulose and hydroxypropylmethylcellulose were efficient antinucleant polymers to increase the permeation of ampicillin sodium.