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Abstract

UV And Visible Spectrophotometric Analysis Of Pioglitazone Hydrochloride In Bulk And Tablets

Author(s): R. S Mehta, D. M Patel, K. K Bhatt, M. B Shankar

Two simple, accurate and economical spectrophotometric methods in ultraviolet and visible region were developed for the determination of pioglitazone hydrochloride in bulk drag and in pharmaceutical formulation. In method A pioglitazone hydrochloride showed λmax at 269 nm in 0.2 N sulphuric acid solution, showing linearity in the concentration range of 10-60 μg/ml whereas in method B pioglitazone hydrochloride was reacted with diazotized sulphanilic acid in an alkaline medium. Yellowish orange coloured chromogen showed λmax at 420 nm, showing linearity in the concentration range of 10-50 μg/ml. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.