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Abstract

UV spectroscopic and colorimetric methods for the estimation of Gatifloxacin in tablet dosage forms

Author(s): K Ilango, P Valentina, KS Lakshmi, Arvind Canhea, Sapana Rachel Abraham, V Bhaskar Raju, A Kiran Kumar
Department of Pharmaceutical Chemistry, S.R.M. College of Pharmacy, Kattankulathur-603 203, India

Correspondence Address:
K Ilango Department of Pharmaceutical Chemistry, S.R.M. College of Pharmacy, Kattankulathur-603 203 India E-mail: [email protected]


Two simple and sensitive spectroscopic methods in ultra violet and visible region, were developed for the estimation of gatifloxacin in pharmaceutical dosage forms. Method A is based on gatifloxacin, showing absorption maximum at 295 nm, in methanol. The method B is based on the reaction of gatifloxacin, with 0.2% w/v 3-methyl-2-benzthiazolinone hydrazone reagent in presence of 1% w/v ferric chloride solution, to yield a yellow orange colour. This colour has a characteristic light absorption in the visible region, with absorption maximum at 433 nm. These methods obey Beer's law in the concentration range of 2 to 10 µg/ml and 50 to 150 µg/ml, respectively. The proposed method is precise, accurate, and reproducible, and can be extended to the analysis of gatifloxacin in tablet formulations.



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