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Abstract

Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets

Author(s): R Jain, SK Kashaw, Rishab Jain, P Mishra, DV Kohli

A simple, accurate and economic spectrophotometric method for the determination of aripiprazole in tablet formulation is proposed. In the present method acidic solution of the aripiprazole formed colored ion-association complexes with bromocresol green, soluble in chloroform. Yellowish orange chromogen showed λmax at 414 nm and obeyed Beer’s law in the concentration range of 10-60 µg/ml. Statistical analysis and recovery studies validated the method. The proposed method is rapid, precise and accurate and can be applied for the routine estimation of aripiprazole in the laboratory.



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