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2-Naphthyloxy Derivatives Of N,N-Substituted Acetamides : Synthesis And Pharmacological Evaluation

Author(s): Poonam Piplani, D. P Jindal, Pooja Gupta, Ruchi Malik, H Tiwari, S. K Kulkarni

The present research was designed to synthesize some 2-naphthyloxy derivatives of N,N-substituted acetamides employing the secondary amino moiety and insertion of-OCH2-group between the aromatic ring and the side chain.2-Naphthol was condensed with methylchloroacetate followed by fusion with different amines to give target compounds 3a-3f. The compounds synthesized after pharmacological investigations have been found to possess significant antiamnesic activity when compared with piracetam. Compounds 3b, 3d, 3f showed dose dependent antiamnesic effect with 3b being most potent. Further, neuropsychopharmacological studies (hypnotic, anticonvulsant, antianxiety, locomotor, muscle relaxant, antidepressant and antiamnesic activities) on 3b confirmed its memory enhancing potential which was comparable to piracetam, a known nootropic agent.