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A Comparative Evaluation Of Permeability And Drug Release From Cellulose Acetate Microcapsules Prepared By Two Complex Emulsion Methods

Author(s): K. P. R Chowdary, K Siva Rama Prasad

Cellulose acetate microcapsules of indomethacin and diclofenac were prepared by emulsification - coacervation (Ec) and emulsification-solvent evaporation (ESE) methods. Microcapsules prepared by ESE method were denser, less permeable, and showed slower release than those prepared by EC method. In both the cases drug release depended on wall thickness and size of the microcapsules and followed first order kinetics.


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