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A facile synthesis, in vitro antiinflammatory and antioxidant activity of novel benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles

Author(s): SR Malladi1, R Anisetti2, PR Rao2
1Department of Pharmaceutical Chemistry, Vaageswari College of Pharmacy, India 2Department of Pharmacy, University College of Technology, Osmania University, India

Correspondence Address:
R Anisetti Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500 007 India E-mail: [email protected]

The synthesis benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles (5a-j) were achieved by cyclocondensation of arylidene amino-benzo[d]imidazole-2-thiols (3a-j) with mercaptoacetic acid followed by cyclization with 2-(phenylmethylene)malononitrile. Further more, the present study aimed at the evaluation of in vitro antiinflammatory activity and antioxidant activity of synthetic compounds. All tested compounds showed appreciable activity against the standard drugs.

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