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Abstract
A method for content uniformity determination of atenolol and losartan potassium in combined tablet dosage form
Author(s): SA Shah, RB Vyas, BA Vyas, NR Maniyar, RS Chauhan, DR Shah
Department of Quality Assurance, Maliba Pharmacy College, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi 394 350, Dist. Surat, Gujarat, India
Correspondence Address:
R B Vyas Department of Quality Assurance, Maliba Pharmacy College, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi 394 350, Dist. Surat, Gujarat India E-mail: ruchivyas23@yahoo.co.in
Department of Quality Assurance, Maliba Pharmacy College, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi 394 350, Dist. Surat, Gujarat, India
Correspondence Address:
R B Vyas Department of Quality Assurance, Maliba Pharmacy College, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi 394 350, Dist. Surat, Gujarat India E-mail: ruchivyas23@yahoo.co.in
A simple, accurate, rapid, specific and reproducible UV spectrophotometric method was developed for estimation of content uniformity of atenolol and losartan potassium in its combined tablet dosage form. The method involves formation and solving the simultaneous equation using 226.4 and 254 nm as two wavelengths for atenolol and losartan, respectively. Developed method was employed to determine the atenolol and losartan content in ten individual tablet units of five market formulations. Methanol was used as solvent. The method was validated. From the results, it was concluded that all brands are within the content uniformity limit, 85-115%.
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