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Abstract

A New Spectrophotometric Method For The Determination Of Ceterizine Hydrochloride In Pharmaceutical Preparations And Biological Samples

Author(s): K. C Ramesh, M. B Melwanki, B. G Gowda, J Seetharamappa, J Keshavayya

A sensitive and rapid extractive spectrophotometric method was developed for the assay of ceterizine hydrochloride in bulk drug, pharmaceutical preparations, urine and blood samples. The method was based on the formation of a chloroform soluble ion-pair complex between ceterizine hydrochloride with thymol blue in an acidic buffer. The complex showed absorption maximum at 413 nm with molar absorptivity of 4.2 X 103l/cm.mol. The system obeyed Beer's law in the concentration range of 3-60 μg/ml (r=0.9992). The results obtained by the proposed method were compared statistically by means of Student t-test and by the F- test with those of the reported method. The two were shown to be in good agreement. No interference was observed from common pharmaceutical excipients.

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