All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


A Pan-Cancer Analysis of Oncogenic Role of PPFIA4 in Human Tumors

Author(s): Yu Xing, Zili Zhang, Wenqing Gao , Weiliang Song and Tong Li*
The Third Central Clinical College of Tianjin Medical University, 1The Third Central Hospital of Tianjin, 2Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases of The Third Central Hospital of Tianjin, Hedong, Tianjin 300170, China

Correspondence Address:
Tong Li, The Third Central Clinical College of Tianjin Medical University, Hedong, Tianjin 300170, China, E-mail:

Although new cell-based research suggests a link between PPFIA4 and colon adenocarcinoma cancer, there is currently no pan-cancer study available. Using The Cancer Genome Atlas datasets, we firstly investigated the possible oncogenic function of PPFIA4 in 33 tumors. We discovered that PPFIA4 is substantially expressed in most malignancies and is associated with tumor patient prognosis. Furthermore, missense mutation and amplification of the PPFIA4 gene were the most common types of genetic change. In contrast to lung squamous cell carcinoma, tumor purity in prostate adenocarcinoma was strongly negatively connected with PPFIA4 expression and considerably positively correlated with the amount of infiltration of cluster of differentiation 8+ T cells, dendritic cells, macrophages, cluster of differentiation 4+ T cells, B cells and neutrophils in the tumor microenvironment. PPFIA4 expression in bladder cancer and lung squamous cell carcinoma is a strong correlation with the expression levels of tumor microenvironment, M1 and M2 macrophages, which are seen in the majority of monocyte marker groups. Furthermore, the functional mechanisms of PPFIA4 were influenced by chemical synaptic transmission as well as the development of the nervous system. In summary, our work provided essential insights into PPFIA4 dysregulation in pan-cancer and prompted potential molecular mechanisms in the progression of cancer, which highlight its potential therapeutic target for patients.

Full-Text | PDF

Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report