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A Retrospective Study on Bacteria Causing Blood Stream Infection: Antibiotics Resistance and Management

Author(s): S. K. Sarkar, A. Bhattacharyya, K. Paria1, and S. M. Mandal2*
Sanjiban Hospital, Fuleswar, Howrah-711 316, 1Nightingale Hospital, Kolkata-700 071, 2Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur-721 302, India

Correspondence Address:
entral Research Facility, Indian Institute of Technology Kharagpur, Kharagpur-721 302, India, E-mail:

Sepsis is one of the major cause of morbidity and mortality from infants to adults. It is most important to determine the infected bacterial species found in bloodstream and its antibiotic susceptibility pattern for appropriate treatment. Overall fifteen hundred patients’ data were incorporated into our study, collected from Sanjiban Hospital, Howrah, West Bengal, India. Out of 1500 samples, 190 neonates and 250 adults were positive for bacterial sepsis. The strains expressing extended-spectrum β-lactamases are major threat as therapeutic options are limited. Among the isolates, Gram-positive bacteria were predominated (53.36 %) over Gram-negative bacteria (46.64 %) and Staphylococcus aureus was the most frequent isolate (37.6 %) followed by Pseudomonas aeruginosa (16 %), Escherichia coli (13.60 %), Klebsiella sp. (12.8 %), coagulase-negative Staphylococci (12.4 %), Acinetobacter sp. (4 %) and Enterococci sp.(2.8 %). Levofloxacin was revealed to be more active against all the Gram-negative isolates along with carbapenems, aminoglycosides (except Klebsiella sp.) and polymyxin-resistant strains. Levofloxacin gave superior coverage against both Gram-positive and Gram-negative bacteria whereas most of the penicillins and cephalosporins were found to be ineffective against both Gram-positive and Gram-negative isolates.

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