Abstract

This study is a comprehensive analysis that aims to explore the pharmacological targeting and neuroprotective effects of acupuncture combined with pharmacology for the treatment of neurodegenerative diseases. The paper reviews the clinical research progress, pharmacological targeting mechanism and neuroprotective mechanism of acupuncture combined with pharmacology for different types of neurodegenerative diseases (such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc.). The paper shows that acupuncture combined with pharmacology can effectively clear or inhibit the aggregation and deposition of neurodegenerative proteins (such as beta-amyloid, alpha-synuclein or huntingtin, etc.), improve the structure and function of neurons, regulate oxidative stress, mitochondrial function, inflammatory response, autophagy disorder, neuronal apoptosis and other signaling pathways, protect neurons from damage, improve the neurological function and quality of life of patients, and reduce the adverse reactions of drugs. The paper provides theoretical basis and guidance for the application of acupuncture combined with pharmacology in the treatment of neurodegenerative diseases.