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Abstract

A Sample And Sensitive Reverse-Phase High Performance Liquid Chromatographic Method For The Determination Of Celecoxib In Rat Plasma

Author(s): M.N Reddy, P Sujatha, A.S Chauhan, S Ramakrishna, P.V Diwan

A simple reversed-phase liquid chromatography method was developed for the quantitative determination of cyclooxygenase-2 inhibitor celecoxib in small volume of rat plasma. The method is simple, sensitive, and highly selective and involves single step extraction of plasma with methanol, with as low as 0.1 ml of rat plasma. The retention time of celecoxib was 5.4 min. The method has been validated for linearity precision, accuracy and inter- intra day variation. Recoveries of celecoxib were around 78 % over the calibration curve range. The method was found to be suitable in studying the pharmacokinetic aspects of celecoxib during the preliminary studies in rats.

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