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Abstract

AIDS: A review of targets and approaches for treatment

Author(s): SD Gupta, Suman Ramteke, A Gupta, N.S.H.N Moorthy
School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Gandhinagar, Bhopal-462 036, India

Correspondence Address:
N.S.H.N Moorthy School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Gandhinagar, Bhopal-462 036 India E-mail: [email protected]


Untreated HIV infection is characterized by a gradual deterioration of immune function. Most notably, crucial immune cells known as CD4 positive T lymphocytes are disabled and killed during the typical course of infection. These T lymphocyte cells play central role in the immune response. The study of HIV structure, genome and its life cycle has revealed many exciting target sites for acquired immunodeficiency syndrome treatment. Many conventional treatments for acquired immunodeficiency syndrome are merely capable of prolonging the patient's life but are unable to completely eradicate the virus as the virus mutates rapidly and develops resistance. So there are many recent novel approaches under consideration like integrase inhibitor, fusion inhibitors and ribozymes for the treatment of acquired immunodeficiency syndrome.

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