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Abstract

All Trans Retinoic Acid Reverses Hypoxia Related Retinal Neurodegeneration in Mice

Author(s): Aimei Tang and Yanli Zhu*
Department of Pediatrics, Maternal and Child Health Hospital of Lianshui County, 1Lianshui County People’s Hospital, Lianshui, Huaian 223400, China

Correspondence Address:
Yanli Zhu, Lianshui County People’s Hospital, Lianshui, Huaian 223400, China, E-mail: 1455336972@qq.com


Increasing numbers of children are suffering from hypoxia-related visual impairments such as retinopathy of prematurity. This study aimed to investigate whether all trans retinoic acid reverses hypoxia related impairments in retinal vasculature. Oxygen induced retinopathy model was established in mouse and the expression of ciliary neurotrophic factor, vascular endothelial growth factor and hypoxia inducible factor 1 was detected. We found that ciliary neurotrophic factor level decreased and vascular endothelial growth factor and hypoxia inducible factor 1 levels increased in model mice. However, all trans retinoic acid suppressed the expression of retinal vascular endothelial growth factor and hypoxia inducible factor 1 while upregulated retinal ciliary neurotrophic factor expression in model mice. In conclusion, all trans retinoic acid can reverse the effects of hypoxia on retinal neovascularization and attenuate retinal neurodegeneration. All trans retinoic acid is a potential agent for the prevention and therapy of retinopathy of prematurity.

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Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report