All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

An Evaluation of Fluorouracil Plus Paclitaxel and Oxaliplatin as a First-Line Treatment for Advanced Gastric Squamous Cell Carcinoma

Author(s): Mi Liu, B. Feng, Mingxin Zhang, H. Yan, Ya Lan and Jie Qin*
Department of Gastroenterology, The First Affiliated Hospital of Xi’an Medical University, Xi’an, 1Department of Oncology, Yan’an University Affiliated Hospital, Yan’an, Shanxi Province 716099, 2Department of Gastroenterology, Shangluo Central Hospital, Shangluo, Shanxi Province 726099, China

Correspondence Address:
Jie Qin, Department of Gastroenterology, The First Affiliated Hospital of Xi’an Medical University, Xi’an, Shanxi Province 726099, China, E-mail: [email protected]

To explore the clinical efficacy of oxaliplatin combined with tegio in the treatment of elderly advanced gastric signet-ring cell carcinoma, and to analyze the role of serum cancer embryo antigen, carbohydrate antigen 199, albumin and total protein levels in the evaluation of chemotherapy efficacy. 85 patients with advanced gastric cell carcinoma were selected and randomly divided into control groups (n=42, general treatment chemotherapy) and treatment group (n=43, on the basis of the monotherapy group, added oxaliplatin fluorouracil, paclitaxel treatment). Paclitaxel 135 mg/m2 viably for 3 h, calcium folinate 400 mg/m2 (levolenic acid calcium 200 mg/m2) for 2 h, simultaneous oxaliplatin 85 mg/m2 for 2 h, followed by continuous intravenous infusion of fluorouracil 2200-2400 mg/m2 for 46 h (using a portable pump), 14 d for a cycle comparing serum carcinoembryonic antigen before and after chemotherapy in two groups, carbohydrate antigen 199, albumin and total protein levels. Objective response rate and median survival time were observed. The median survival time of the treatment group was 11.7 mo and the objective response rate was 32.5 % and the control was controlled. Changes in serum carcinoembryonic antigen, carbohydrate antigen 199 and albumin were associated with the efficacy of advanced gastric print cell carcinoma (p<0.01), while the total serum protein level was not statistically significantly correlated with the efficacy of chemotherapy (p>0.05). Safety and survival were evaluated in all patients and short-term efficacy was evaluated in 66 patients. The disease control rate was 89.4 % and the objective response rate was 48.5 %. Average follow-up was 13.2 mo, median progression-free survival 7 mo (95 % confidence interval: 6.85 to 7.15 mo), median total overall survival 10.6 mo (95 % confidence interval: 9.86 to 11.3 mo). The main grade III/IV adverse reactions were neutropenia (22.1 %) and peripheral neurotoxicity (10.3 %). The treatment group had better efficacy in patients with advanced gastric cell carcinoma. Serum carcinoembryonic antigen, carbohydrate antigen 199 and albumin can be used to predict the efficacy of chemotherapy for advanced gastric print cell carcinoma. Serum total protein levels were minimally correlated with the efficacy of chemotherapy and were not statistically significant.

PDF

 
 
Google scholar citation report
Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report