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Abstract

An overview of the method of positional scanning synthetic combinatorial libraries

Author(s): G Mariappan, Nihar Bhuyan, JP Mohanty, Subarna Ganguli, D Dhachinamoorthi
Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim-737 132, India

Correspondence Address:
G Mariappan Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim-737 132 India E-mail: [email protected]


Combinatorial chemistry is a novel synthetic strategy which leads to produce a large number of chemical libraries with predetermined structures. The advances in the research of combinatorial library synthesis and screening methods have enabled the medicinal chemists to identify highly active compounds rapidly. This method has revolutionized basic research and drug discovery. A number of combinatorial methods have been developed to boost the morale of medicinal chemists. Out of those, positional scanning synthesis plays a significant role to generate libraries from libraries. This approach is capable of producing infinite libraries. Our aim is to explore this method to understand the principle of synthesis and deconvolution screening methods to identify individual active compounds.

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