Abstract

This study attempts to discuss the clinical efficacy of tenofovir tablets combined with Liqi Fuzheng decoction (consist of Radix pseudostellariae 30 g, fruit of citron or trifoliate orange 9 g, inula 12 g, Pinellia ternata 9 g, pericarpium citri reticulatae viride 9 g, dried tangerine peel 9 g, costus root 9 g, corydalis 15 g, rice sprout 30 g, malt 30 g, dandelion 30 g, its indications for gastrointestinal disorders) in the treatment of acquired immune deficiency syndrome patients with immune reconstitution and liver and kidney damage. We selected 70 acquired immune deficiency syndrome patients treated in our dermatology department from January 2019 to June 2020. Then randomly divided them into observation group (35 patients treated with tenofovir tablets and Liqi Fuzheng decoction) and control group (35 patients treated with tenofovir tablets), compare the serum cytokine concentration levels and immune function index levels of both groups of patients before and after treatment, and compare the changes in liver and kidney function and clinical efficacy after treatment. After 6 mo treatment, interleukin-2, interleukin-5, interleukin-4, interleukin-10, interferon gamma and interferon alpha levels in the serum of observation group decreased more remarkably than control group, it possessed statistical significance (p<0.05); observation group had greater decrease trend of cluster of differentiation 8+ T lymphocytes and regulatory T cells than control group, which was statistically significant (p<0.05); observation group had greater uptrend of cluster of differentiation 4+ T lymphocytes and T helper 17 cells than control group, which was statistically significant (p<0.05). Both groups had no remarkable divergence in liver and kidney function (alanine transaminase, creatinine) before and after treatment, and it possessed no statistical significance (p>0.05). The total clinical effective rate of observation group (94.29 %) was remarkably higher than control group (82.86 %), it possessed statistical significance (p<0.05). The combination of tenofovir tablets and Liqi Fuzheng decoction for long term treatment of acquired immune deficiency syndrome patients’ increases cluster of differentiation 4+ T lymphocytes and T helper 17 cells levels, improves the clinical efficiency and has no liver and kidney damage. It is a safe and effective treatment plan and is worth popularizing in clinic.