Abstract

This study was to analyze the effects of grain amaranth hypoglycemic powder on blood glucose and oxidative stress in patients with type 2 diabetes mellitus. A total of 100 type 2 diabetes mellitus patients admitted to our hospital from March 2020 to March 2021 were randomly divided into an observation group and a control group, with 50 patients in each group. The control group was treated with metformin tablets orally and the observation group was additionally treated with grain amaranth hypoglycemic powder and both were treated for 3 mo. Fasting plasma glucose, hemoglobin A1c, 2 h postprandial blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, homeostatic model assessment for insulin resistance, fasting insulin, homeostasis model assessment-beta, malondialdehyde, reactive oxygen species, glutathione peroxidase, risk of complications and adverse reactions were observed. After 1 mo and 3 mo of treatment, fasting plasma glucose, hemoglobin A1c, 2 h postprandial blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, homeostatic model assessment for insulin resistance, fasting insulin, homeostasis model assessment-beta, malondialdehyde and reactive oxygen species in the observation group were lower, whereas high-density lipoprotein cholesterol, homeostatic model assessment for insulin resistance and glutathione peroxidase were higher than those in the control group. After 3 mo of treatment, the observation group was at low risk of developing complications and had no difference in the incidence of adverse reactions. Grain amaranth hypoglycemic powder can effectively reduce oxidative stress, improve insulin resistance, regulate glucose and lipids, and reduce the risk of complications in patients with type 2 diabetes mellitus.