Abstract

This report intends to study the efficacy of curcumin and alcohol-containing mouthwashes in the treatment of chronic periodontal disease. 114 chronic periodontal disease patients, admitted between November 2018 and November 2022 were considered and all the patients received basic treatment for chronic periodontal disease. On this basis, research group (n=59) was treated with curcumin and alcohol-containing mouthwashes, while the control group (n=55) was treated with compound gargle solution chlorhexidine gluconate. The curative effect and adverse reactions such as discomfort, oral inflammation, and tissue edema were studied. Similarly, periodontal indices like probing depth, sulcus bleeding index, attachment loss, gingival crevicular fluid inflammation, high-sensitivity c-reactive protein, tumor necrosis factor-alpha, interleukin-8, and serum matrix metalloproteinases were compared between the two groups. The data showed an evidently higher overall response rate of treatment in the research group compared with the control group; the incidence of adverse reactions was similar in the two groups. Markedly lower post-interventional probing depth, sulcus bleeding index, attachment loss, high-sensitivity c-reactive protein, tumor necrosis factor-alpha, interleukin-8, and serum matrix metalloproteinases was observed in the research group, compared with the pre-intervention values and the control group. Conclusively, the curcumin and alcohol-containing mouthwash is effective in treating chronic periodontal disease, which can improve the periodontal indices of patients and inhibit gingival crevicular fluid inflammation.