Abstract

To observe and analyze the relationship between the severities of sarcopenia complicated with diabetes in elderly men and bone density, pulmonary function, irisin and interleukin-6. 80 male patients aged 55 y or older with diabetes and 100 male patients aged 55 y or older with sarcopenia complicated with diabetes that was treated in our hospital from 2018 to 2020 were selected. All enrolled patients underwent bone density and pulmonary function tests, as well as plasma irisin levels and serum inflammatory factor detection, to analyze their relationship. Using sarcopenia, body mass index and glycated hemoglobin as independent variables and whether sarcopenia was complicated as the dependent variable, the results of multiple logistic regression analysis showed that sarcopenia in elderly male diabetic patients was an independent risk factor for osteoporosis (p<0.05); interleukin-2 of the study group was 160.1±32.4 ng/l, interleukin-4 was 13.5 (7.5-21.8) ng/l, interleukin-6 was 4.3 (1.8-8.1) ng/l, interleukin-8 was 14.5 (7.8-32.0) ng/l, forced expiratory volume 1/forced vital capacity was 65.44±14.68 % and forced expiratory volume 1 predicted value was 67.28±29.95 %. Through correlation analysis, it was found that the four-limb skeletal muscle index was correlated with pulmonary function indicators (forced expiratory volume 1/forced vital capacity and forced expiratory volume 1) and interleukin-6 (p<0.05); forced expiratory volume 1 was negatively correlated with interleukin-8 level (t=-340, p<0.05); the bone mineral content and irisin levels of the study group were lower than those of the reference group. Using bone mineral content and irisin as independent variables and whether sarcopenia was complicated as the dependent variable, the results of multiple logistic regression analysis showed that bone mineral content and irisin were independent protective factors for sarcopenia complicated with diabetes in elderly men (both p<0.05). The severity of sarcopenia complicated with diabetes in elderly men is closely related to bone density, pulmonary function, irisin, and interleukin-6 which have certain clinical value.