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Anti HIV And Antibacterial Activities Of Some Disubstitutedquinazolones And Their Bio-Isostere Disubstitutedthienopyrimidones

Author(s): V Alagarsamy, U. S Pathak, D Sriram, S. N Pandeya, E De. Clearcq

Anti HIV and antibacterial activity of some 2,3-disubstitutedquinazolones, 2-substituted-[1,3,4]- thiadiazoloquinazolones and their bio-isostere-[1,3,4]-thiadiazolothienopyrimidones were determined. Among the compounds tested for antiHIV activity, the 2-methyl -[1,3,4]-thiadiazolo [2,3-b]-6,7,8,9-tetrahydrobenzo(b)thieno-[3,2-e]-pyrimidin-5(4H)-one (USP/VA-2) gave maximum protection against HIV-2 (ROD). The compounds 2-(4-methoxyphenylamino)-[l,3,4]-thiadiazolo-[2,3-b]-6,7-dimethylthieno-[3,2-e]-pyrimidin-5(4H)-one (USP/VA-1) and USP/VA-2 were exhibited comparable antibacterial activity with the standard amoxycill in against Escherichia coli.


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