All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Antibacterial and antifungal activities of 2-arylidene-4-(4-methylphenyl)but-3-en-4-olides and their pyrrolone derivatives

Author(s): A Husain1, SM Hasan1, S Lal2, MM Alam1
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, India 2 Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India

Correspondence Address:
A Husain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062 India E-mail: [email protected]


Starting from 3-3-(4-methyl-benzoyl)propionic acid and using appropriate reagents, some new 2-arylidene-4-(4-methylphenyl)but-3-en-4-olides (IIIa-g) and their corresponding pyrrolone derivatives (IVa-d) have been synthesized. These compounds were evaluated for their antibacterial activity against Staphylococcus aureus and Escherichia coli as well as antifungal activity against Candida albicans . The compounds have considerable antifungal activity and moderate antibacterial activity.

Full-Text | PDF

 
 
List of Supporting Conferences