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Abstract
Antibacterial and antifungal activities of 2-arylidene-4-(4-methylphenyl)but-3-en-4-olides and their pyrrolone derivatives
Author(s): A Husain1, SM Hasan1, S Lal2, MM Alam1
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, India 2 Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India
Correspondence Address:
A Husain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062 India E-mail: drasifhusain@yahoo.com
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, India 2 Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India
Correspondence Address:
A Husain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062 India E-mail: drasifhusain@yahoo.com
Starting from 3-3-(4-methyl-benzoyl)propionic acid and using appropriate reagents, some new 2-arylidene-4-(4-methylphenyl)but-3-en-4-olides (IIIa-g) and their corresponding pyrrolone derivatives (IVa-d) have been synthesized. These compounds were evaluated for their antibacterial activity against Staphylococcus aureus and Escherichia coli as well as antifungal activity against Candida albicans . The compounds have considerable antifungal activity and moderate antibacterial activity.
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