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Abstract

Antibacterial and antifungal activities of some novel thiolactosides

Author(s): DV Mangte1, SP Deshmukh1, DD Bhokare2, Aarti R Deshpande2
1 P. G. Department of Chemistry, Shri Shivaji College, Akola - 444 001, India 2 Department of Microbiology, Shankarlal Khandelwal College, Akola - 444 002, India

Correspondence Address:
S P Deshmukh P. G. Department of Chemistry, Shri Shivaji College, Akola - 444 001 India E-mail: [email protected]


A series of novel thiolactosides like S -hepta- O -acetyllactosyl-1-arylisothiocarbamides (1a-g) and hepta- O -acetyl lactosyl arydithiocarbamates (2a-g) were prepared by the interaction of hepta- O -acetyl lactosyl bromide with arylthiocarbamides and ammonium aryldithiocarbamates respectively. Similarly (hepta- O -acetyl lactosyl)-1,5-disubstituted-2-isothiobiurets (3a-g) 1,5-disubstituted-2,4-isodithiobiurets (4a-g) and-1,2,4-thiadiazolines (5a-g) were synthesized by the interaction of (1a-g) with phenyl isocyanate, phenyl isothiocyonate and S -chloro- N -phenyl isothiocarbamoyl chloride respectively. The compounds 3-Aryl-2,6-diphenylimino 4-S-hepta- O -acetyl lactosyl-2,3dihydro-1,3,5-thiadiazines hydrochlorides (6a-g) were prepared by the interaction of (4a-g) with phenyl isocyanodichloride. In the present investigation activities of these thiolactosides against pathogenic bacteria and fungi such as E. coli, S. aureus, P. vulgaris, Salmonella typhi, Candida guilliermondii and A. niger are discussed.

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