All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Antidiabetic and antihyperlipidemic effects of thespesia populnea fruit pulp extracts on alloxan-induced diabetic rats

Author(s): SN Belhekar1, PD Chaudhari2, JS Saryawanshi3, KK Mali4, RB Pandhare5
1Department of Pharmacology, Vinayaka Mission College of Pharmacy, Salem-636 308, India 2Department of Pharmaceutics, Modern College of Pharmacy, Pune-411 044, India 3Department of Pharmacognosy, Satara College of Pharmacy, Satara-415 104, India 4Department of Pharmaceutics, Satara College of Pharmacy, Satara-415 104, India 5Department of Pharmacology, MES's College of Pharmacy, Ahmednagar-414 105, India

Correspondence Address:
S N Belhekar Department of Pharmacology, Vinayaka Mission College of Pharmacy, Salem-636 308 India E‑mail: [email protected]


Present study was carried to find out the antihyperglycemic and antihyperlipidemic activity of ethanol and aqueous extract of Thespesia populnea fruit pulp on alloxan-induced diabetic rats. Diabetes was induced in rats by administration of alloxan (150 mg/kg, i.p.). After the successful induction of experimental diabetes, the rats were divided into five groups each comprising a minimum of six rats. Phytochemical analysis and acute toxicity study of extracts was also done. The effects of extracts and metformin on fasting blood glucose and plasma lipid were examined for 28 days. Statistical analysis was carried out by using analysis of variance followed by Dunnet's multiple comparison test and paired t-test were done as the test of significance using GraphPad Prism. P≤0.05 was considered as the minimal level of statistical significance. Therapeutic dose of extract was found to be 200 mg/kg on the basis of acute toxicity study. Aqueous and alcoholic extract showed a significant reduction in blood glucose levels as well as a lipid profile of diabetic rats at the end of 28 th day of treatment. However, in groups treated with plant extract the reduction in the blood glucose and improvement in lipid profile was slightly less than that achieved with the standard group (metformin). From this study, it can be concluded that ethanol and aqueous extract of Thespesia populnea exhibited significant antihyperglycemic and antihyperlipidemic effects on alloxan-induced diabetic rats.

Full-Text | PDF