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Antifungals: Need to search for a new molecular target

Author(s): AT Sangamwar2, UD Deshpande2, SS Pekamwar2
2Department of Pharmaceutics, Nanded Pharmacy College, Nanded-431 605, India 2School of Life Sciences, S. R. T. M. University, Nanded-430 606, India 2Department of Pharmaceutical Chemistry, Nanded Pharmacy College, Nanded-431 605, India

Correspondence Address:
A T Sangamwar Department of Pharmaceutics, Nanded Pharmacy College, Nanded-431 605 India, [email protected]

In the 1990s, drug resistance has become an important problem in a variety of infectious diseases including human immunodeficiency virus infection, tuberculosis, and other bacterial infections which have profound effects on human health. At the same time, there have been dramatic increase in the incidence of fungal infections, which are probably the result of alterations in immune status associated with the acquired immuno deficiency syndrome epidemic, cancer chemotherapy, and organ and bone marrow transplantation. The rise in the incidence of fungal infections has exacerbated the need for the next generation of antifungal agents, since many of the currently available drugs have undesirable side effects, are ineffective against new or reemerging fungi, or lead to the rapid development of the resistance. This review will focus on the pathogenic yeast Candida albicans , since a large body of work on the factors and mechanism associated with antifungal drug resistance in this organism is reported sufficiently. It will certainly elaborate the probable molecular targets for drug design, discovered to date.

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