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Abstract

AntiHIV And Antibacterial Activities Of 2-Substituted Thiadiazolo Quinazolines

Author(s): V Alagarsamy, U.S Pathak, R Venkateshperumal, S Meena, K Thirumurugan, V Raja Solomon, E De Clercq

AntiHIV and antibacterial activities of 2-substituted-(1,3,4)-thiadiazolo (2,3-b) quinazolin-5(4H)- ones, were determined. Among the compounds tested for antiHIV activity, the compound VA5 gave maximum protection against HIV-2 (ROD).The compound VA2 (at 100μg/rnl) exhibited equivalent antibacterial activity with the standard ciprofloxacin (at 10 μg/ml) against Klebsiella pneumoniae, Bacillus subtilis, Staphylococcus epidermitis, Shigella flexnari and Citrobacter ferundi.

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