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Abstract

AntiHIV, Antibacterial And Antifungal Activities Of Some 2,3-Disubstituted Quinazolin-4(3H)-Ones

Author(s): V Alagarsamy, R Revathi, S Meena, K. V Ramaseshu, S Rajasekaran, E De Clerco

The title compounds 2-mercapto-3-(substitutedmethylamino) quinazolin-4(3H)-ones were synthesized by condensing the active hydrogen atom of 3-amino group of 3-amino-2-mercapto quinazolin- 4(3H)-one with formaldehyde and the desired amines. Investigation of antimicrobial activity of the compounds was performed by agar dilution method against 6 pathogenic bacteria, 3 pathogenic fungi and antiHlV activity against replication of HIV-1 (IIIB) and HIV-2 (ROD) in MT-4 cells. The compounds exhibited significant antibacterial and antifungal activities.

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