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Antihyperglycemic activity of various fractions of Cassia auriculata linn. in alloxan diabetic rats

Author(s): SJ Surana, SB Gokhale, RB Jadhav, RL Sawant, Jyoti B Wadekar
P. D. V. V. P. F's College of Pharmacy, Vilad Ghat, Post MIDC, Ahmednagar-414 111, India

Correspondence Address:
Jyoti B Wadekar Pushkar Apartment, Shivaji Chowk, Jangam Lane, Rahuri (Dist. Ahmednagar)-413 705 India E-mail: [email protected]

Present work describes the potent antidiabetic fraction from flowers of Cassia auriculata Linn. Hydromethanolic extract along with its ethyl acetate and n-butanol fractions were evaluated for antidiabetic activity in alloxan-induced diabetes in rats. The n-butanol fraction exhibited significant reduction (p<0.001) in blood glucose levels and was also found effective in restoring the blood lipids and proteins to normal level. The activity was found comparable with standard drug phenformin. The hydromethanolic extract and its fractions were subjected to preliminary qualitative chemical investigations which indicated the presence of phenolic compounds, carbohydrates, tannins, steroids and amino acids.

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