Abstract

Author(s): SR Deorukhakar¹, A Dethe¹, RR Vohra¹, R Ghosh¹, J Chaudhary², V Kadam^1
1Department of Pharmacology, Bharati Vidyapeeth's College of Pharmacy, Navi Mumbai-400 614, India ²Exotic Naturals, 118 Mourya House, Link Road, Andheri (W), Mumbai-400 053, India

Correspondence Address:
R R Vohra Department of Pharmacology, Bharati Vidyapeeth's College of Pharmacy, Navi Mumbai-400 614 India rashmi.v@rediffmail.com

The antiinflammatory activity of the polyherbal formulation Entox® was investigated in rats for acute and sub acute models of inflammation using carrageenan-induced rat paw edema and cotton pellet granuloma methods respectively at a dose of 300 mg/kg and 600 mg/kg administered orally. The formulation in doses of 300 mg/kg and 600 mg/kg showed 51.61% and 54.84% inhibition of paw edema, respectively at the end of 3 h. The percent inhibition of granuloma by cotton pellet method was 27.92% and 53.17%, respectively. The formulation showed a significant antiinflammatory activity in both the experimental models and the activity was comparable to that of the standard drug, indomethacin.

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