All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

"Anti-inflammatory activity of flavone and its methoxy derivatives-a structure activity study".

Author(s): NS Muthiah, S Viswanathan, P Thirugnansambantham, MK Reddy, V. Vijayasekaran
Medicinal Chemistry Research Centre, Institute of Pharmacology, Madras Medical College, Madras - 600 003,

Correspondence Address:
N S Muthiah Medicinal Chemistry Research Centre, Institute of Pharmacology, Madras Medical College, Madras - 600 003

Flavone, its various methoxy derivatives and flavanone were investigated for their anti-inflammatory activity in carrageenin- induced paw edema in mice (acute) and cotton pellet granuloma in rats (chronic). In the acute study flavone,3,6,7, and 2,-methoxy flavones exhibited a dose related anti-inflammatory activity. However, compounds like flavanone, 5-and4'-methoxy flavones failed to show any anti-inflammatory response. In the chronic model, almost all the compounds except 4' - methoxy flavone exerted dose related anti-inflammatory effect. Thus a definite structure activity relationship could be observed in the anti-inflammatory activity of these compounds.

PDF

 
 
List of Supporting Conferences