All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Antiinflammatory Activity Of Some New 3-Substituted-4-Amino-5-Mercapto-4(H)-1,2,4-Triazoles

Author(s): M. B Talawar, S. C Bennur, S. K Kankanwadi, P. A Patil

Certain new 3-substitued-4-amino-5-mercapto-4(H)-1,2,4-triazoles having anilinomethyl group at the 3- position have been synthesised by the reaction of 4-substitutes anilinoacetic acid hydrazides (2A-F) successively with alcoholic potassium hydroxide – carbon disulfide and hydrazine hydrate. These compounds have been characterized by spectral data and are evaluated for their antiinflammatory activity against carrageenan-induced rat paw edema and cotton pellet granuloma. All the test samples possess significant anti-inflammatory activity at 1st, 3rd, and 6th hour after the carrageenan injection. However, test sample D is devoid of anti-inflammatory activity at first hour.

PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report