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Antioxidant effect of Tinospora cordifolia extract in alloxan-induced diabetic rats

Author(s): V Sivakumar1, MS Dhana Rajan2
1Department of Pharmacy, Sri Lakshmi Narasimha College of Pharmacy, Palluru-517 132, India 2PG and Research Department of Biochemistry, Jaya College of Arts and Science, Thiruninravur-602 024, India

Correspondence Address:
V Sivakumar Department of Pharmacy, Sri Lakshmi Narasimha College of Pharmacy, Palluru-517 132 India E-mail: [email protected]

Many plants are claimed to possess antidiabetic and antioxidant activity. In practice, it is being increasingly recognized to be an alternative approach to modern medicine. This study assess the antioxidant capacity of Tinospora cordifolia stem methanol extract in daily oral administration of 500 mg/kg of body weight for 40 days in alloxan induced diabetic rats. The erythrocytes membrane lipid peroxide and catalase activity was increased where as the activities of superoxide dismutase, glutathione peroxidase were found to be decreased significantly (P<0.01) in alloxan-induced diabetic rats. The levels of lipid peroxide in liver of diabetic rats increased significantly (P<0.01) and catalase, superoxide dismutase, glutathione peroxidase in liver was significantly decreased in alloxan-induced diabetic rats, when compared to normal rats. After treatment of methanol Tinospora cordifolia stem extract brings back to normal (P<0.01) in the erythrocytes membrane and liver cell enzymes activities.

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