Abstract

Several researchers have suggested that the antisense non-coding ribonucleic acid in the INK4 locus long non-coding ribonucleic acid (cyclin-dependent kinase inhibitor 2B antisense ribonucleic acid 1) plays a key role in the pathogenesis of the intracranial aneurysm. However, because single studies are often underpowered due to inadequate sample sizes, the role of the antisense non-coding ribonucleic acid in the INK4 locus rs1333040 polymorphism in intracranial aneurysms has been inconclusive among Asian population. To obtain a comprehensive conclusion, we conducted a meta-analysis with 4260 cases and 14 536 controls to estimate the association between the rs1333040 polymorphism and intracranial aneurysms susceptibility. The electronic databases of PubMed and Embase were searched before May 2022, to identify the relevant literature. Cochran’s Q statistics and the I² test were applied to assess heterogeneity among the included investigations. The summary pooled odds ratios and 95 % confidence intervals were evaluated for the strength of association using the random or fixed-effects model. A total of 6 eligible studies were enrolled in this meta-analysis, involving 4260 cases and 14 536 controls. The pooled results indicated a significant association between the rs1333040 polymorphism and the intracranial aneurysm in Asians under 3 genetic models (TT vs. CC: Odds ratio=1.48, 95 % confidence interval=1.30-1.70; TC vs. CC: Odds ratio=1.20, 95 % confidence interval=1.05-1.38; dominant model-TT+TC vs. CC: Odds ratio=1.34, 95 % confidence interval=1.18-1.53). The findings of this meta-analysis emphasize the rs1333040 polymorphism as a common risk factor for intracranial aneurysms in Asian people.