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Antiulcer And Gastric Acid Inhibitory Activity Of ZD 7114, A ?3-Adrenoceptor Agonist In Rats

Author(s): A Paul, S Patel, R Sevak, Sunita Goswami, D. D Santani

The antiulcer activity of ZD 7114, aβ3, - adrenoceptor agonist was studied in aspirin plus pylorus ligation induced gastric ulcer in rats and its effect on continuous acid secretion was also studied against in vivo as well as in vitro models. For comparison, the effect of isoprenaline and salbutamol was studied simultaneously in all experimental models. In gastric ulcer model, β-adrenoceptor agonists at all doses were found to be highly effective in affording gastroprotection. ZD 7114 treatment caused significant reduction in acid secretion in vivo model whereas no significant change was observed in vitro model of continuous acid secretion. In contrary to this no significant change in acid secretion was observed by treatment with isoprenaline and salbutamol in vivo model and a significant rise in acid secretion in vitro model.


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