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Abstract

Application Of Abelmoschus Esculentus Gum As A Mini-Matrix For Furosemide And Diclofenac Sodium Tablets

Author(s): S. I Ofoefule, A Chukwu

A gel forming polysaccharide gum obtained from the pods of Abelmoschus esculentus was employed as a mini matrix in a new sustained release tablet formulations of furosemide (a diretic) and diclofenac sodium (a non steroidal anti inflammatory agent). Sustained release performance of the formulations was compared with formulations containing sodium carboxymethylcellulose (NaCMC, 500 mPa) in similar experimental conditions. Abelmoschus esculentus gum was as good as NaCMC in prolonging the release of furosemide and diclofenac sodium from the compressed tablets-Times for 50% (t50%) and 75% (t75%) indicated relatively faster release of furosernide in simulated intestinal fluid (SIF). Similar trends are observed in the case of diclofenac sodium. A reduction in the solubility of diclofenac sodium was observed and this was caused by the presence of sodium and potassium in SIF. These new formulations which utilize a plant hydrogel as mini matrix offer the advantage of simplicity and economy.

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