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Abstract

Application of Box-Behnken Design for Formulation Parameters of Eslicarbazepine Tablets

Author(s): Paravastu Venkata Kamala Kumari*, S. R. Yarraguntla, Mantha Sharmila and Ekshitha Gulibindala
Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam, Andhra Pradesh 530049, India

Correspondence Address:
Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam, Andhra Pradesh 530049, India, E-mail: kamalaparavastu@gmail.com


Current research has been done to develop statistically and optimized immediate release tablets for eslicarbazepine. Nineteen formulations of eslicarbazepine acetate immediate release tablets are prepared by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed to study how selected independent variables affect dependent responses. After the initial test, three independent items were selected as follows; polyvinylpyrrolidone (A), tapioca starch (B) and galbanum gum (C). Responses to measure were the time of disintegration (Y1) and in vitro drug release at 45 min (Y2). In accordance with the independent variables, three different levels were established as the lowest, highest and middle variables tested. The predicted formula formulated with the Box-Behnken statistical design consisted of polyvinylpyrrolidone, tapioca starch and galbanum gum at the optimum levels of 2.49, 2.77 and 3 respectively.

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