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Application of cellulase in the sterlity test for fortified procaine pencillin.

Author(s): PS Channe, BS Deshpande, JG Shewale
R & D, Hindustan Antibiotics Ltd., Pimpri, Pune-411 018,

Correspondence Address:
P S Channe R & D, Hindustan Antibiotics Ltd., Pimpri, Pune-411 018

Cellulase from Aspergillus niger was used to hydrolyse carboxymethylcellulose (CMC) present in the fortified procaine pencillin formulation. The filtration time during the sterlity test was reduced from 300 min to 4 min. The approach can be extended to sterility testing of other pharmaceutical preparations containing CMC as an ingredient.


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