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Application Of Differential Scanning Calorimetry (DSC) To Preformulation Compatibility Studies Between Chloroquine Phosphate And Tablet Excipients

Author(s): Deepak A Hegde, Darshana D Hegde, M. S Nagarsenker, H. P Tipnis

DSC was employed as a means to investigate the physicochemical compatibility between chloroquine phosphate (CQP) and a number of commonly used excipients. CQP was found to be compatible with microcrystalline cellulose (MCC), starch, polyvinyl pyrrolidone (PVP K-30), sodium starch glycolate (SSG), magnesium stearate, talc, hydroxypropyl methyl cellulose (HPMC), polyethylene glycol (PEG-4000) and titanium dioxide (Ti02). Gelatin was found to interact with CQP. Methyl and propyl paraben showed interaction in the 1:1 ratio. However, when studied at a 1:100 ratio, no significant interaction was observed. Although gelatin was found to interact with CQP, one cannot conclusively state that this incompatibility will be encountered on storage at room temperature.


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