Abstract

To investigate the effect and value of thyroid stimulating hormone and thyroglobulin ratio, B-ultrasound and emission computed tomography imaging in the preoperative differentiation of benign and malignant thyroid nodules. 272 patients who underwent thyroid nodule surgery were divided into benign group and malignant group, and the diagnostic performance of a single index in the differentiation of benign and malignant thyroid nodules was analyzed. The levels of thyroid stimulating hormone, thyroglobulin antibody and thyroid imaging reporting and data system in malignant group were higher than those in benign group and the thyroglobulin level in benign group was higher than that in malignant group (p<0.05). Thyroid imaging reporting and data system has a larger area under the receiver operating characteristic curve in the differentiation of benign and malignant thyroid nodules. In thyroglobulin antibody negative group, the thyroid stimulating hormone/thyroglobulin ratio of benign patients was lower than that of malignant patients (p<0.05). Meanwhile, receiver operating characteristic curve reflected that thyroid stimulating hormone/ thyroglobulin ratio had certain diagnostic performance. In the large nodule group, the Y value under the multiple regression models had a larger area under the line and the area under the line of thyroid emission computed tomography imaging was the smallest. In the small nodule group, the Y value was higher than other detection methods, which was 0.794. The accuracy of thyroid stimulating hormone and thyroglobulin ratio, B-ultrasound and emission computed tomography imaging in the differentiation of benign and malignant thyroid nodules was more than 98 %. The combination of thyroid stimulating hormone and thyroglobulin ratio, B-ultrasound and emission computed tomography imaging is effective and has great advantages in the differentiation of benign and malignant thyroid nodules before operation.