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Abstract

Association between Lung Microbiota Dysbiosis and Sepsis Induced Acute Respiratory Distress Syndrome

Author(s): Jingkun Ye, Zhuandi Lin*, Yuxia He and Shan Li
Department of Respiratory Medicine, Intensive Care Unit, Panyu Central Hospital, Guangzhou, Guangdong Province 511400, China

Correspondence Address:
Zhuandi Lin, Department of Respiratory Medicine, Intensive Care Unit, Panyu Central Hospital, Guangzhou, Guangdong Province 511400, China, E-mail: 13710911343@163.com


Sepsis is associated with acute respiratory distress syndrome, which has a significant impact on the prognosis of patients. Several studies have shown that the microbiota plays a significant role in sepsisinduced acute respiratory distress syndrome, but the relationship between the microbiota and sepsisinduced acute respiratory distress syndrome is not fully understood. We conducted a case-control and single-center study in 19 sepsis-induced acute respiratory distress syndrome patients and 36 sepsis-noninduced acute respiratory distress syndrome patients to investigate the clinical features and microbiota expression. There were 55 subjects enrolled, 19 of whom suffered acute respiratory distress syndrome due to sepsis. A significant increase in the abundance of Pseudomonas aeruginosa, leptospiral virus, Cytomegalovirus, Klebsiella pneumoniae, Streptococcus pneumoniae, Candida albicans, Escherichia coli, Epstein-Barr virus and Staphylococcus aureus. Besides, expressions of peripheral T lymphocytes (cluster of differentiation 3+, cluster of differentiation 4+ and cluster of differentiation 3+, cluster of differentiation 8+) was much higher in the sepsis-induced acute respiratory distress syndrome group than that in the sepsis non-induced acute respiratory distress syndrome group. The acute physiology and chronic health evaluation II scores, duration of mechanical ventilation and mortality with 28 d and 90 d were much higher in the sepsis-induced acute respiratory distress syndrome group. Patients with sepsis-induced acute respiratory distress syndrome had worse clinical outcomes and a higher expression of peripheral T lymphocytes, as well as the relative abundance of microbiota dysbiosis.

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