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Abstract

Association between Serum Calprotectin Expression and Disease Activity in Patients with Inflammatory Bowel Disease

Author(s): R. D. CHEN, YUN YUN HU, QIAN CHEN, HAN XU AND M. J. QIAN*
Department of Gastroenterology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, Jiangsu 215000, China

Correspondence Address:
J. QIAN, Department of Gastroenterology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, Jiangsu 215000, China; E-mail: [email protected]


Serum calprotectin expression and correlation with disease activity in patients with inflammatory bowel disease is the main objective. 128 patients with inflammatory bowel disease with complete clinical diagnosis and no blood relationship with each other, including 64 patients with Crohn’s disease and 64 patients with ulcerative colitis, were collected from January 2018 to January 2020 in our hospital and 64 examiners with normal colonoscopy results were selected as the control group levels. The differences in serum troponin levels between the inflammatory bowel disease group and the normal control group were compared, the differences in serum troponin levels between inflammatory bowel disease patients with different activity levels were compared, the relationship between serum troponin levels and the clinical features of inflammatory bowel disease was analyzed, and finally the diagnostic efficacy of serum troponin levels in inflammatory bowel disease was analyzed. The results showed that serum troponin levels were significantly higher in the inflammatory bowel disease group compared with the control group, but the difference between the Crohn’s disease and ulcerative colitis groups was not statistically significant. Singlefactor analysis of variance showed statistically significant (p<0.05) differences in serum troponin levels between Crohn’s disease and ulcerative colitis groups in mild activity, moderate activity, severe activity and remission, with severe activity being the highest, followed by moderate activity, mild activity again and remission being the lowest. The specificity of serum calprotectin level in diagnosing inflammatory bowel disease was 97.2 % and the sensitivity was 79.7 %; the sensitivity of C-reactive protein test was 73.2 % and the specificity was 90.8 %; the sensitivity of Erythrocyte sedimentation rate test was 65.9 % and the specificity was 86.1 %, which was significant. Serum calprotectin levels are associated with the activity of inflammatory bowel disease and may become one of the clinically valuable indicators to determine the activity of inflammatory bowel disease inflammation.

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