Abstract

Betacyclodextrin inclusion complexes of ciprofloxacin, norfloxacin and tinidazole are prepared and incorporated in ocular implants to try as sustained release ocular preparations of anti-infective drugs for prolonged use. It is found that the stability of drugs improved after complexation. The release characteristics are also better. The ocular preparations may be very useful for treating ophthalmic ailments due to infection requiring chronic treatment with anti-infective drugs.