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Binding Of Phenylalkylamines At Serotonin Receptors : A Quantitative Analysis

Author(s): R. C Sharma, S Tiwari, P Singh

A quantitative structure-activity relationship (QSAR) analysis of the binding activity data to the 5-HT1c and the 5-HT2 receptors for the congeneric series of phenylalkylamines was performed and the results there of revealed that the pharmacophoric requirements for both are nearly similar with only likely difference at 5- position of the phenyl ring. Further, for both subtypes, moderately hydrophobic substituent at 4-rign and less bulky groups at X are predicted to cause enhancement in potency of the ligand. A substituents at 2-ring appears to have synergistic influence.


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